A minor fraction of base J in kinetoplastid nuclear DNA is bound by the J-binding protein 1.
作者信息
Toaldo Cristiane Bentin, Kieft Rudo, Dirks-Mulder Anita, Sabatini Robert, van Luenen Henri G A M, Borst Piet
机构信息
The Netherlands Cancer Institute, Division of Molecular Biology and Centre of Biomedical Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
出版信息
Mol Biochem Parasitol. 2005 Sep;143(1):111-5. doi: 10.1016/j.molbiopara.2005.05.001.
Abstract
摘要
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A minor fraction of base J in kinetoplastid nuclear DNA is bound by the J-binding protein 1.动质体核DNA中一小部分的碱基J与J结合蛋白1结合。
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JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes.JBP1和JBP2是两种不同的胸苷羟化酶，参与非洲锥虫基因组DNA中J的生物合成。
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The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase.锥虫中与DNA碱基J结合的蛋白质具有胸苷羟化酶的特征。
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本文引用的文献
1
Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania.利什曼原虫中一个必需基因被靶向作用后线性反向重复扩增子的形成。
Nucleic Acids Res. 2005 Mar 21;33(5):1699-709. doi: 10.1093/nar/gki304. Print 2005.
2
Regulation of trypanosome DNA glycosylation by a SWI2/SNF2-like protein.一种SWI2/SNF2样蛋白对锥虫DNA糖基化的调控
Mol Cell. 2005 Feb 4;17(3):441-51. doi: 10.1016/j.molcel.2004.12.022.
3
J-binding protein increases the level and retention of the unusual base J in trypanosome DNA.J结合蛋白可提高锥虫DNA中异常碱基J的水平及保留率。
Mol Microbiol. 2002 Oct;46(1):37-47. doi: 10.1046/j.1365-2958.2002.03144.x.
4
Site-specific interactions of JBP with base and sugar moieties in duplex J-DNA. Evidence for both major and minor groove contacts.JBP与双链J-DNA中碱基和糖基部分的位点特异性相互作用。存在大沟和小沟接触的证据。
J Biol Chem. 2002 Aug 2;277(31):28150-6. doi: 10.1074/jbc.M201487200. Epub 2002 May 23.
5
Recognition of base J in duplex DNA by J-binding protein.J结合蛋白对双链DNA中碱基J的识别。
J Biol Chem. 2002 Jan 11;277(2):958-66. doi: 10.1074/jbc.M109000200. Epub 2001 Nov 7.
6
Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.串联重复DNA是布氏锥虫中β-D-葡糖基羟甲基尿嘧啶部分取代胸腺嘧啶的靶点。
Mol Biochem Parasitol. 2000 Jul;109(2):133-45. doi: 10.1016/s0166-6851(00)00247-4.
7
Base J originally found in kinetoplastida is also a minor constituent of nuclear DNA of Euglena gracilis.最初在动质体中发现的碱基J也是纤细裸藻核DNA的次要成分。
Nucleic Acids Res. 2000 Aug 15;28(16):3017-21. doi: 10.1093/nar/28.16.3017.
8
The African trypanosome genome.
Int J Parasitol. 2000 Apr 10;30(4):329-45. doi: 10.1016/s0020-7519(00)00015-1.
9
The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans.修饰碱基J是动质体原生动物中一种新型DNA结合蛋白的作用靶点。
EMBO J. 1999 Nov 15;18(22):6573-81. doi: 10.1093/emboj/18.22.6573.
10
Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.布氏锥虫中修饰的DNA碱基β-D-葡萄糖基羟甲基尿嘧啶的生物合成与功能
Mol Cell Biol. 1998 Oct;18(10):5643-51. doi: 10.1128/MCB.18.10.5643.
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