Liang Jie, Adamian Larisa, Jackups Ronald
Department of Bioengineering, University of Illinois at Chicago, M/C563, 835 S. Wolcott Avenue, Chicago, IL 60612-7340, USA.
Trends Biochem Sci. 2005 Jul;30(7):355-7. doi: 10.1016/j.tibs.2005.05.003.
Membrane proteins have important roles in many cellular processes. Computational analysis of their sequences and structures has provided much insight into the organizing principles of transmembrane helices. In a recent study, the membrane-water interface region was examined in detail for the first time. The results have revealed that this interface region has an important role in constraining protein secondary structure. This study raises new questions and opens up new directions for studying membrane proteins.
膜蛋白在许多细胞过程中发挥着重要作用。对其序列和结构的计算分析为跨膜螺旋的组织原则提供了很多见解。在最近的一项研究中，首次对膜 - 水界面区域进行了详细研究。结果表明，该界面区域在限制蛋白质二级结构方面具有重要作用。这项研究提出了新问题，并为研究膜蛋白开辟了新方向。
