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眼见为实——体外和体内药物递送的可视化

Seeing is believing--visualizing drug delivery in vitro and in vivo.

作者信息

Swartz Harold

机构信息

Hinman Box 7785, 702 Vail Building, Dartmouth Medical School, Hanover, NH 03755-3863, USA.

出版信息

Adv Drug Deliv Rev. 2005 Jun 15;57(8):1085-6. doi: 10.1016/j.addr.2005.01.019.

Abstract

Illustrations have always been essential in spreading new scientific and medical ideas. The extraordinary progress of spectroscopic and imaging methods allows the visualization of the performance of drug delivery systems under both in vitro and in vivo conditions. Detailed and quantitative information about the location and concentration of the drug and carrier can be obtained as a function of time, thereby enabling a more profound understanding of biological effects. This information is crucial to the design of optimized drug delivery systems. This issue of ADDR features novel, non-radioactive methods potentially useful for drug delivery scientists in selecting the most appropriate imaging techniques for solving the drug delivery problem at hand.

摘要

插图在传播新的科学和医学理念方面一直至关重要。光谱学和成像方法的非凡进展使得在体外和体内条件下都能够可视化药物递送系统的性能。可以获得有关药物和载体的位置及浓度随时间变化的详细定量信息,从而能够更深入地了解其生物学效应。这些信息对于优化药物递送系统的设计至关重要。本期《药物递送与处置进展》专题介绍了新颖的非放射性方法,这些方法可能有助于药物递送领域的科学家选择最合适的成像技术来解决当前的药物递送问题。

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