Corá L A, Romeiro F G, Stelzer M, Américo M F, Oliveira R B, Baffa O, Miranda J R A
Departamento de Física e Biofísica, Instituto de Biociências, Botucatu-SP, Laboratório de Biomagnetismo, Universidade Estadual Paulista, UNESP, CXP 510, CEP 18618-000, Botucatu, São Paulo, Brazil.
Adv Drug Deliv Rev. 2005 Jun 15;57(8):1223-41. doi: 10.1016/j.addr.2005.01.026. Epub 2005 Apr 9.
Conventionally, pharmaceutical substances are administered orally because the gastrointestinal tract possesses the appropriate features for drug absorption. Nevertheless, the gastrointestinal tract physiology is complex and influenced by many factors. These factors must be completely understood for the optimization of oral drug delivery systems. Although in vitro tests provide information about release and drug absorption profiles, in vivo studies are essential, due to the biological variability. Several techniques have been employed in an attempt to conveniently characterize the behavior of solid dosage forms in vivo. The noninvasive biomagnetic technique of alternate current biosusceptometry (ACB) has been used in studies focusing on gastrointestinal motility and, more recently, to evaluate the performance of magnetic dosage forms. This article will discuss the main characteristics of AC biosusceptometry and its applicability for determination of the relationship between the human gastrointestinal tract and orally administered pharmaceutical dosage forms.
传统上，药物经口服给药，因为胃肠道具备药物吸收的适当特性。然而，胃肠道生理过程复杂且受多种因素影响。为优化口服给药系统，必须全面了解这些因素。尽管体外试验可提供有关药物释放和吸收曲线的信息，但由于生物变异性，体内研究必不可少。人们已采用多种技术试图方便地表征固体剂型在体内的行为。交变电流生物磁测量法（ACB）这种非侵入性生物磁技术已用于专注于胃肠动力的研究，最近还用于评估磁性剂型的性能。本文将讨论交流生物磁测量法的主要特性及其在确定人体胃肠道与口服药物剂型之间关系方面的适用性。
