Jaafar-Maalej Chiraz, Andrieu Véronique, Elaissari Abdelhamid, Fessi Hatem
Université Claude Bernard Lyon 1, Laboratoire d'Automatique et de Génie des Procédés (LAGEP), Lyon, France.
Expert Opin Drug Deliv. 2009 Sep;6(9):941-59. doi: 10.1517/17425240903117244.
The pulmonary route has been used with success for the treatment of both lung (asthma) and systemic diseases (diabetes). The fate of an inhaled drug (absorption and deposition) within human lungs has great importance, particularly in drug development and quality control. This article focuses on the various methods that are now applied for aerosol fate investigation. Several assessment methods, ranging from in vitro assays (impaction and optical systems) to in vivo experiments (imaging and pharmacological methods), are described. In vitro assays measure particle size distribution and emitted drug dose, which could be predictive of lung deposition pattern in vivo. However, in vivo methods provide direct information about the concentration and the location of inhaled drug within lung. Advantages and limitations of the different techniques are identified. In addition to these experimental techniques, mathematical deposition models, elaborated in more realistic conditions and designed to predict the fate of inhaled particles, are also illustrated.
肺部给药途径已成功用于治疗肺部疾病（哮喘）和全身性疾病（糖尿病）。吸入药物在人肺内的命运（吸收和沉积）非常重要，特别是在药物开发和质量控制方面。本文重点介绍了目前用于气雾剂命运研究的各种方法。描述了几种评估方法，从体外试验（撞击法和光学系统）到体内实验（成像和药理学方法）。体外试验测量粒径分布和喷出药物剂量，这可以预测体内肺部沉积模式。然而，体内方法提供了关于吸入药物在肺内的浓度和位置的直接信息。确定了不同技术的优点和局限性。除了这些实验技术外，还阐述了在更实际条件下精心设计以预测吸入颗粒命运的数学沉积模型。
