Nomura Kinya, Melotto Maeli, He Sheng-Yang
Department of Energy Plant Research Laboratory and Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA.
Curr Opin Plant Biol. 2005 Aug;8(4):361-8. doi: 10.1016/j.pbi.2005.05.005.
Despite impressive advances in the study of plant resistance to pathogens, little is known about the molecular basis of plant susceptibility to virulent pathogens. Recent progress in susceptible plant-Pseudomonas syringae interactions has provided a glimpse into the battles fought between plants and bacterial pathogens. A key step for pathogenesis appears to be the suppression of host defenses. Suppression of host defenses, including basal defense, gene-for-gene resistance and nonhost resistance, is a key step for pathogenesis. Defense suppression is mediated by bacterial effector proteins, which are secreted through the type III secretion system, and by coronatine, a bacterial toxin that structurally and functionally mimics methyl jasmonate, a plant defense signaling molecule.
尽管在植物对病原体抗性的研究方面取得了令人瞩目的进展，但对于植物对毒性病原体易感性的分子基础却知之甚少。感病植物与丁香假单胞菌相互作用的最新进展，让人得以一窥植物与细菌病原体之间的斗争。致病的关键步骤似乎是抑制宿主防御。抑制宿主防御，包括基础防御、基因对基因抗性和非寄主抗性，是致病的关键步骤。防御抑制由细菌效应蛋白介导，这些蛋白通过III型分泌系统分泌，还由冠菌素介导，冠菌素是一种细菌毒素，在结构和功能上模拟茉莉酸甲酯，一种植物防御信号分子。
