Bell Stephen D
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK.
Trends Microbiol. 2005 Jun;13(6):262-5. doi: 10.1016/j.tim.2005.03.015.
There is now an increasing body of data available on the DNA-binding properties of several putative transcriptional regulators in the Archaeal domain of life. The evidence points to simple models of promoter occlusion or facilitated recruitment of basal machinery for repressors and activators, respectively. However, little is known about the co-factor requirements, in vivo mechanisms and targets of many of these regulators. It is anticipated that the application of post-genomic technologies will begin to shed light on this fascinating area.
目前，关于生命古菌域中几种假定转录调节因子的DNA结合特性，已有越来越多的数据。证据分别指向阻遏物和激活物的启动子封闭或促进基础机制募集的简单模型。然而，对于许多这些调节因子的辅助因子需求、体内机制和靶点，我们所知甚少。预计后基因组技术的应用将开始为这个迷人的领域带来启示。
