Thanvi B, Munshi S K, Dawson S L, Robinson T G
Department of Integrated Medicine, Leicester General Hospital, Gwendolen Road, University Hospitals of Leicester NHS Trust, Leicester LE5 4PW, UK.
Postgrad Med J. 2005 Jun;81(956):383-8. doi: 10.1136/pgmj.2003.016774.
Cervicocerebral arterial dissections (CAD) are an important cause of strokes in younger patients accounting for nearly 20% of strokes in patients under the age of 45 years. Extracranial internal carotid artery dissections comprise 70%-80% and extracranial vertebral dissections account for about 15% of all CAD. Aetiopathogenesis of CAD is incompletely understood, though trauma, respiratory infections, and underlying arteriopathy are considered important. A typical picture of local pain, headache, and ipsilateral Horner's syndrome followed after several hours by cerebral or retinal ischaemia is rare. Doppler ultrasound, MRI/MRA, and CT angiography are useful non-invasive diagnostic tests. The treatment of extracranial CAD is mainly medical using anticoagulants or antiplatelet agents although controlled studies to show their effectiveness are lacking. The prognosis of extracranial CAD is generally much better than that of the intracranial CAD. Recurrences are rare in CAD.
颈脑动脉夹层(CAD)是年轻患者中风的重要原因,占45岁以下患者中风的近20%。颅外颈内动脉夹层占所有CAD的70%-80%,颅外椎动脉夹层约占15%。虽然创伤、呼吸道感染和潜在的动脉病变被认为是重要因素,但CAD的病因发病机制尚未完全明确。局部疼痛、头痛和同侧霍纳综合征的典型表现,数小时后继以脑或视网膜缺血的情况较为罕见。多普勒超声、MRI/MRA和CT血管造影是有用的非侵入性诊断检查。颅外CAD的治疗主要是药物治疗,使用抗凝剂或抗血小板药物,尽管缺乏对照研究来证明其有效性。颅外CAD的预后通常比颅内CAD好得多。CAD复发很少见。