Chaturvedi U C, Shrivastava Richa, Nagar Rachna
K.G. Medical University, Lucknow, India.
Indian J Med Res. 2005 May;121(5):639-52.
The extent of cumulative disease burden caused by dengue virus has attained an unprecedented level in recent times with sharp increase in the size of human population at risk. Dengue disease presents highly complex medical, economic and ecologic problems. The surge in publications on the development of dengue vaccines, taking advantage of new generation of biotechnology techniques indicates the profound interest and urgency in the scientific and medical communities in combating this disease. This review summarizes the importance of critical subjects like pathogenesis of dengue haemorrhagic fever and inadequacy of animal model that have adversely affected dengue vaccine development. Further, the remarkable progresses so far made in dengue vaccine research not only employing a diverse range of new strategies but also re-using old techniques to improve the existing vaccines, have been presented. The efficacy and safety of some of the new vaccine candidates have been evaluated and proven in human preclinical/clinical trials. Besides the technical advancement in vaccine development, vaccine safety and vaccine formulation have been examined.
近年来，随着高危人群数量的急剧增加，登革病毒所造成的累积疾病负担程度达到了前所未有的水平。登革热疾病呈现出高度复杂的医学、经济和生态问题。利用新一代生物技术开发登革热疫苗的相关出版物激增，这表明科学界和医学界在抗击这种疾病方面有着浓厚的兴趣和紧迫感。本综述总结了登革出血热发病机制和动物模型不足等关键问题的重要性，这些问题对登革热疫苗的开发产生了不利影响。此外，还介绍了登革热疫苗研究目前取得的显著进展，这些进展不仅采用了各种新策略，还重新运用旧技术来改进现有疫苗。一些新候选疫苗的有效性和安全性已在人体临床前/临床试验中得到评估和验证。除了疫苗开发的技术进步外，还探讨了疫苗安全性和疫苗配方。
