Chang Gwong-Jen J, Kuno Goro, Purdy David E, Davis Brent S
Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Rampart Road, CDC-Foothill Campus, Fort Collins, CO 80521, USA.
Expert Rev Vaccines. 2004 Apr;3(2):199-220. doi: 10.1586/14760584.3.2.199.
Lately, the magnitude of cumulative diseases burden caused by flaviviruses, such as dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, West Nile virus and yellow fever virus, has reached an unprecedented level with the sizes of human and animal populations at risk increasing sharply. These diseases present highly complex medical, economic and ecologic problems, some effecting primarily human and others affecting human, livestock and wildlife. The large body of recent publications on the development of vaccines taking advantage of new generations of bio-engineering techniques clearly reflects the profound interests and deep sense of urgency in the scientific and medical communities in combating those diseases. This review reveals a collection of remarkable progresses thus far made in flaviviral vaccine research not only employing a diverse range of new strategies but also re-tooling old techniques to improve the existing vaccines. The efficacy and safety of some of the new vaccine candidates have been evaluated and proven in human clinical trials. Besides the technical advancement in vaccine development, in this review, the importance of somewhat neglected and yet critical subjects, such as adequacy of animal model, vaccine safety, vaccine formulation and delivery, complication in serodiagostics and economic factor, was examined in-depth.
最近，由黄病毒引起的累积疾病负担的规模，如登革热病毒、日本脑炎病毒、蜱传脑炎病毒、西尼罗河病毒和黄热病病毒，随着面临风险的人类和动物种群数量急剧增加，已达到前所未有的水平。这些疾病呈现出高度复杂的医学、经济和生态问题，一些主要影响人类，另一些则影响人类、牲畜和野生动物。最近大量利用新一代生物工程技术开发疫苗的出版物清楚地反映了科学界和医学界对对抗这些疾病的浓厚兴趣和深深的紧迫感。这篇综述揭示了迄今为止黄病毒疫苗研究取得的一系列显著进展，不仅采用了多种新策略，还对旧技术进行了改进以完善现有疫苗。一些新候选疫苗的有效性和安全性已在人体临床试验中得到评估和验证。除了疫苗开发的技术进步外，本综述还深入探讨了一些被忽视但至关重要的主题的重要性，如动物模型的充分性、疫苗安全性、疫苗配方和递送、血清诊断中的并发症以及经济因素。
