Nakamichi Ken-Ichi, Tachibana Shintaro
Department of Orthopaedic Surgery, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan.
Muscle Nerve. 2005 Sep;32(3):364-7. doi: 10.1002/mus.20363.
In idiopathic carpal tunnel syndrome (CTS), the median nerve is enlarged within the carpal tunnel due to intraneural connective tissue proliferation. Because hypercholesterolemia, especially increase in low-density lipoprotein (LDL), has been associated with fibrogenesis, we investigated the association of median nerve cross-sectional area and prevalence of idiopathic CTS with serum lipid measurements in middle-aged patients and controls. We found that nerve area and prevalence of CTS were correlated with serum LDL levels. Thus, high LDL levels in middle age are a risk factor for idiopathic CTS, suggesting that the LDL-correlated median nerve enlargement increases the volume of the carpal tunnel contents.
在特发性腕管综合征（CTS）中，由于神经内结缔组织增生，正中神经在腕管内增粗。鉴于高胆固醇血症，尤其是低密度脂蛋白（LDL）升高，与纤维生成有关，我们研究了中年患者和对照组中正中神经横截面积以及特发性CTS患病率与血脂测量值之间的关联。我们发现神经面积和CTS患病率与血清LDL水平相关。因此，中年时LDL水平升高是特发性CTS的一个危险因素，这表明与LDL相关的正中神经增粗增加了腕管内容物的体积。
