Patro Birija S, Chintalwar Gajanan J, Chattopadhyay Subrata
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Nat Prod Res. 2005 Jun;19(4):347-54. doi: 10.1080/14786410412331280032.
The lipid peroxidation inhibitory activities of four hydroxyxanthones, isolated from the whole plant Swertia decussata, were evaluated for the first time. The most promising antioxidant among the xanthones, 1,7,8-trihydroxy-3-methoxyxanthone (swertianine, 4) was also tested for its scavenging potential against DPPH and superoxide radicals. The data clearly revealed good antioxidant activity of the xanthones, especially 4 which also showed strong protection against y-ray induced pBR322 DNA damage. A comparison of the radioprotecting activities of the monomethylated tetrahydroxyxanthone 4 with that of its congener, 1,3,7-trihydroxy-8-methoxyxanthone (5) revealed that the radioprotecting activity was not affected by the position of methylation.
首次评估了从全草獐牙菜中分离得到的四种氧杂蒽酮的脂质过氧化抑制活性。在这些氧杂蒽酮中最具前景的抗氧化剂1,7,8 - 三羟基 - 3 - 甲氧基氧杂蒽酮（獐牙菜苦苷，4）也被测试了其对DPPH和超氧自由基的清除潜力。数据清楚地表明了氧杂蒽酮具有良好的抗氧化活性，尤其是4，其还对γ射线诱导的pBR322 DNA损伤表现出强大的保护作用。将单甲基化的四羟基氧杂蒽酮4与其同系物1,3,7 - 三羟基 - 8 - 甲氧基氧杂蒽酮（5）的辐射防护活性进行比较，结果表明辐射防护活性不受甲基化位置的影响。
