Chérigo Lilia, Polanco Venancio, Ortega-Barria Eduardo, Heller Maria V, Capson Todd L, Rios Luis Cubilla
Laboratory of Natural Products, Faculty of Natural and Exact Sciences and Technology Apdo. 0824, University of Panama, Panama City, Republic of Panama.
Nat Prod Res. 2005 Jun;19(4):373-7. doi: 10.1080/1478641042000261950.
Bioactivity-guided fractionation of a MeOH-EtOAc extract from the young leaves of Nectandra lineata (Lauraceae), using a Trypanosoma cruzi bioassay resulted in the isolation of a novel norlignan 3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy (1), together with the known compound, 3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene (2). Compounds 1 and 2 were shown to inhibit the growth of T. cruzi epimastigotes in axenic culture.
采用克氏锥虫生物测定法，对樟科平滑钩樟幼叶的甲醇 - 乙酸乙酯提取物进行生物活性导向分离，得到一种新型去甲木脂素3'-甲氧基 - 3,4 - 亚甲二氧基 - 4',7 - 环氧 - 9 - 降 - 8,5'-新木脂素 - 9'-乙酰氧基（1），以及已知化合物3'-甲氧基 - 3,4 - 亚甲二氧基 - 4'-7 - 环氧 - 9 - 降 - 8,5'-新木脂素 - 7,8'-二烯（2）。化合物1和2在无菌培养中显示出抑制克氏锥虫前鞭毛体生长的作用。
