来自钝叶豆瓣绿的杀锥虫四氢呋喃木脂素。

Trypanocidal tetrahydrofuran lignans from Peperomia blanda.

作者信息

Felippe Lidiane Gaspareto, Baldoqui Debora Cristina, Kato Massuo Jorge, Bolzani Vanderlan da Silva, Guimarães Elsie Franklin, Cicarelli Regina Maria Barreto, Furlan Maysa

机构信息

Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900 Araraquara, SP, Brazil.

出版信息

Phytochemistry. 2008 Jan;69(2):445-50. doi: 10.1016/j.phytochem.2007.08.012. Epub 2007 Sep 20.

DOI:10.1016/j.phytochem.2007.08.012

PMID:17888465

Abstract

Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastereomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y.

摘要

从钝叶豆瓣绿地上部分分离得到了5个四氢呋喃木脂素和2个已知黄酮。通过对其光谱数据（包括gHMQC和gHMBC）的解析阐明了分离得到的木脂素的结构。分别根据NOESY相互作用和光学性质确定了分离物的相对构型和绝对构型。其中4个木脂素为非对映异构体，而1个具有混合生物合成来源。除1个木脂素外，其余所有木脂素在针对克氏锥虫Y菌株的无鞭毛体进行体外检测时均表现出高杀锥虫活性。