Turiel Esther, Martin-Esteban Antonio
Departamento de Medio Ambiente, INIA, Madrid, Spain.
J Sep Sci. 2005 May;28(8):719-28. doi: 10.1002/jssc.200400076.
Molecularly imprinted polymers (MIPs) are tailor-made synthetic polymers with a predetermined selectivity for a given analyte, or group of structurally related compounds, that make them ideal materials for use as stationary phases in affinity chromatography. However, extensive peak broadening and tailing, especially of the more retained compound (normally the template) are often observed. Thus, huge efforts have been made during recent years to use MIPs in capillary electrochromatography, which is inherently a more efficient chromatographic technique than conventional HPLC. Accordingly, this paper gives an overview of the attempts carried out in the recent past to improve the chromatographic performance of MIPs in capillary electrochromatography as well as more recent applications. It is concluded that MIPs are very promising materials for use as selective stationary phases in CEC.
分子印迹聚合物（MIPs）是一种定制的合成聚合物，对给定的分析物或一组结构相关的化合物具有预定的选择性，这使其成为亲和色谱中用作固定相的理想材料。然而，经常观察到峰展宽和拖尾现象严重，尤其是对于保留时间更长的化合物（通常是模板分子）。因此，近年来人们付出了巨大努力将MIPs应用于毛细管电色谱，因为它本质上是一种比传统高效液相色谱更高效的色谱技术。相应地，本文概述了过去为改善MIPs在毛细管电色谱中的色谱性能所做的尝试以及最新的应用。得出的结论是，MIPs作为毛细管电色谱中的选择性固定相是非常有前途的材料。
