来自驱虫斑鸠菊种子的新型甾体化合物。

Novel steroids from the seeds of Centratherum anthelminticum.

作者信息

Mehta B K, Mehta Darshana, Verma Manjul

机构信息

School of Studies in Chemistry, Vikram University, Ujjain--456010, India.

出版信息

Nat Prod Res. 2005 Jul;19(5):435-42. doi: 10.1080/14786410512331330729.

DOI:10.1080/14786410512331330729

PMID:15938188

Abstract

Two novel and two known steroids were isolated respectively from benzene: acetone and ethanolic extracts of the seeds of C. anthelminticum and, identified as (24alpha/R)-Stigmasta-7-en-3-one (1), (24alpha/R)-Stigmasta-7, 9(11)-dien-3-one (2), (24alpha/S)-Stigmasta-5, 22-dien-3beta-ol (3) and (24alpha/S)-Stigmasta-7, 22-dien-3beta-ol (4). The structures were assigned on the basis of their IR, 1H NMR, 13C NMR (DEPT), 2D NMR (1H-1H COSY and 1H-13C COSY), mass spectra, chemical analyses and on comparison with literature values. The novel steroids (1) and (2) were also tested against several human pathogenic bacteria and fungi.

摘要

分别从驱虫豆种子的苯

丙酮提取物和乙醇提取物中分离出两种新型甾体和两种已知甾体，鉴定为(24α/R)-豆甾-7-烯-3-酮(1)、(24α/R)-豆甾-7,9(11)-二烯-3-酮(2)、(24α/S)-豆甾-5,22-二烯-3β-醇(3)和(24α/S)-豆甾-7,22-二烯-3β-醇(4)。根据它们的红外光谱、1H核磁共振、13C核磁共振(DEPT)、二维核磁共振(1H-1H COSY和1H-13C COSY)、质谱、化学分析以及与文献值的比较确定了结构。还对新型甾体(1)和(2)进行了针对几种人类病原菌和真菌的测试。