驱虫斑鸠菊（Centratherum anthelminticum (L) Kuntze）种子的镇痛和解热活性评价
Evaluation of Analgesic and Antipyretic Activities of Centratherum anthelminticum (L) Kuntze Seed.
作者信息
Purnima A, Koti B C, Tikare V P, Viswanathaswamy A H M, Thippeswamy A H M, Dabadi P
机构信息
Department of Pharmacology, KLES's College of Pharmacy, Rajajinagar, Bangalore-560 010, India.
出版信息
Indian J Pharm Sci. 2009 Jul;71(4):461-4. doi: 10.4103/0250-474X.57302.
The study was designed to investigate analgesic and antipyretic activities of petroleum ether and alcohol extracts of Centratherum anthelminticum (L) Kuntze (family: Asteraceae) seeds (100 and 200 mg/kg, p.o.) in brewer's yeast-induced fever model in rats, acetic acid-induced writhing and Eddy's hot plate methods in mice. Both petroleum ether and alcohol extracts showed significant decrease in number of writhes in acetic acid-induced writhing and increase in paw licking time to heat stimuli in the hot plate method. The maximum analgesic activity was observed at 90 min after dosing when compared to control. Both the extracts showed significant inhibition of elevated body temperature when compared to corresponding control. These results suggested that the petroleum ether and alcohol extracts possessed analgesic and antipyretic activities.
本研究旨在通过啤酒酵母诱导大鼠发热模型、乙酸诱导小鼠扭体模型及小鼠热板法，研究驱虫斑鸠菊（菊科）种子的石油醚提取物和乙醇提取物（100和200mg/kg，口服）的镇痛和解热活性。石油醚提取物和乙醇提取物在乙酸诱导的扭体模型中均能显著减少扭体次数，在热板法中能增加对热刺激的舔足时间。与对照组相比，给药后90分钟时镇痛活性最强。与相应对照组相比，两种提取物均能显著抑制体温升高。这些结果表明，石油醚提取物和乙醇提取物具有镇痛和解热活性。
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