Rahman M Mukhlesur, Gibbons Simon, Gray Alexander I
Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK.
Phytochemistry. 2007 Jun;68(12):1692-7. doi: 10.1016/j.phytochem.2007.04.015. Epub 2007 May 30.
Two isoflavanones, 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxyisoflavanone (2) and 4',5-dihydroxy-2',3'-dimethoxy-7-(5- hydroxyoxychromen-7yl)-isoflavanone (4) along with six known compounds including isoflavanones, triterpenes and steroids were isolated from the roots of Uraria picta. The structures of these compounds were established unambiguously by UV, IR, MS and a series of 1D and 2D NMR analyses. The minimum inhibitory concentrations (MIC) for these compounds were found to be in the range of 12.5-200 microg/ml against bacteria (both Gram positive and Gram negative) and fungi.
从毛蔓豆的根部分离出了两种异黄酮，5,7 - 二羟基 - 2'- 甲氧基 - 3',4'- 亚甲二氧基异黄酮（2）和4',5 - 二羟基 - 2',3'- 二甲氧基 - 7 -（5 - 羟基氧色原酮 - 7 - 基）异黄酮（4），以及六种已知化合物，包括异黄酮、三萜和甾体。通过紫外光谱（UV）、红外光谱（IR）、质谱（MS）以及一系列一维和二维核磁共振（NMR）分析明确确定了这些化合物的结构。发现这些化合物对细菌（革兰氏阳性和革兰氏阴性）和真菌的最低抑菌浓度（MIC）在12.5至200微克/毫升范围内。
