Deota P T, Upadhyay P R
Department of Applied Chemistry, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Vadodara--390 001, India.
Nat Prod Res. 2005 Jul;19(5):529-39. doi: 10.1080/14786410512331330558.
Azadirachtin-A (Aza-A, figure 1) was subjected to a variety of synthetic transformations and the antifeedant activity and toxicity of the azadirachtin derivatives were assessed against second instar larvae Spodoptera litura on castor leaves in comparison with the crude material containing 9.14% Aza-A, as well as relatively pure 91% Aza-A. A probable mechanism for the base initiated fragmentation of the diketocarbonate into a decalin fragment and a spiroketal moiety has been proposed. The present study indicates that the combination of insect toxicity and antifeedancy of azadirachtin provides good crop protection.
印楝素 -A（印楝素 -A，图1）经过了多种合成转化，并将印楝素衍生物的拒食活性和毒性与含有9.14%印楝素 -A的粗品以及相对纯的91%印楝素 -A进行比较，评估其对蓖麻叶上斜纹夜蛾二龄幼虫的影响。已提出了一种可能的机制，即二酮碳酸酯在碱引发下断裂成十氢化萘片段和螺缩酮部分。本研究表明，印楝素的昆虫毒性和拒食性相结合可提供良好的作物保护。
