Du Shi-xin, Ji Shi-jun, Sun Kai-lai
Department of Orthopaedics, the First Clinical College of Shantou University, Shantou 515041, China.
Zhonghua Wai Ke Za Zhi. 2005 Apr 15;43(8):505-8.
To explore the possible correlations between clinical and experimental pathological changes of congenital clubfoot and the pathodynamic developmental procedure.
Eighty-three female Wistar rats were administered with retinoic acid on the 10th day after pregnancy. And from February 2001 to February 2004, 48 patients were analyzed with electropysiological examination.
There was clubfoot-like deformity in 53.7% of the experimental fetuses. Persistence of the embryonic position of the talus and tibia in fetuses was observed. Poor overlapping between talus and calcaneus was seen. Cell apoptosis at the anterior corner of spinal cord were seen. Of all the patients, 68.3% were abnormal with electropysiological examination. The pathological sites were frequently localized in lumbarsacral region.
Congenital clubfoot is correlated closely with defects of neural tube and spinal cord.
探讨先天性马蹄内翻足临床及实验病理改变与病理动力学发育过程之间的可能相关性。
妊娠第10天给83只雌性Wistar大鼠施用维甲酸。2001年2月至2004年2月，对48例患者进行电生理检查分析。
53.7%的实验胎儿出现马蹄内翻足样畸形。观察到胎儿距骨和胫骨的胚胎位置持续存在。距骨和跟骨之间重叠不良。可见脊髓前角细胞凋亡。所有患者中，68.3%电生理检查异常。病理部位常位于腰骶部。
先天性马蹄内翻足与神经管和脊髓缺陷密切相关。
