针对结构多样的γ-丁内酯类天然产物类似物的合成方法。

Synthetic approaches towards structurally diverse gamma-butyrolactone natural-product-like compounds.

作者信息

Seitz Michael, Reiser Oliver

机构信息

Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.

出版信息

Curr Opin Chem Biol. 2005 Jun;9(3):285-92. doi: 10.1016/j.cbpa.2005.03.005.

DOI:10.1016/j.cbpa.2005.03.005

PMID:15939330

Abstract

Natural products containing a gamma-butyrolactone ring are abundant in nature; however, few general synthetic approaches to their stereoselective synthesis with broad structural variety are known. In this article, recent developments towards mono- and polycyclic gamma-butyrolactone natural products and analogs are discussed. A special focus is given to asymmetric methods applying transition metal or organocatalysts that allow not only the efficient introduction of a broad variety of functional groups but ideally also the flexible construction of various natural-product-like, polycyclic scaffolds from common precursors.

摘要

含有γ-丁内酯环的天然产物在自然界中广泛存在；然而，很少有能立体选择性合成具有广泛结构多样性的此类化合物的通用方法。在本文中，我们讨论了单环和多环γ-丁内酯天然产物及其类似物的最新研究进展。特别关注了应用过渡金属或有机催化剂的不对称方法，这些方法不仅能有效引入多种官能团，还能理想地从常见前体灵活构建各种类似天然产物的多环骨架。