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[韦格纳肉芽肿病的一个历史病例:发现电磁波的物理学家:海因里希·赫兹]

[A historic case of Wegener's granulomatosis: the physicist who discovered the electromagnetic waves: Heinrich Hertz].

作者信息

Feldmann H

机构信息

Univ.-HNO-Klinik Münster.

出版信息

Laryngorhinootologie. 2005 Jun;84(6):426-31. doi: 10.1055/s-2004-826062.

Abstract

SUMMARY

A diary and an extensive correspondence of Heinrich Hertz and his family provide a meticulous documentation of his life, made available by Albrecht Folsing in 1997 through a carefully investigated biography, which permit the conclusion that H. Hertz died of Wegener's granulomatosis, 45 years before this disease had been explored. WEGENER'S GRANULOMATOSIS: The symptoms of the granulomatosis, that was first described by Friedrich Wegener in 1936 and 1939 are presented in short with literal quotations of the author: It begins with a refractory cold that will last until the end, then follow involvement of the paranasal sinuses, ears, mucous lining of mouth and pharynx, slight fever, weakness, in the final phase dissemination with nephritis, septic fever, arthritis, myalgia, paralyses leading to total immobility, exitus. The etiology is not fully understood but probably based on immunoreaction. H. HERTZ: CURRICULUM VITAE: Born in Hamburg, Germany, in 1857: after secondary school academic training in physics at Dresden, Munic and Berlin. 1885 professor of physics in Karlsruhe, then starting in 1889 at Bonn. 1887/88 exploration of the electromagnetic waves, now the basis for all radio communication, and exploration of the photoelectric effect, the basis of solar techniques. Numerous highranking distinctions. H. HERTZ:

THE CASE HISTORY

The case history is presented in detail based on numerous literal quotations from personal letters and the diary. After a few banal affections involving the teeth and toes the systemic disease became manifest in summer 1892 with a refractory cold which remained the focus of treatment until death. Granulation tissue in the nose that was excised several times: no tuberculosis, no carcinoma. Otitis with purulent mastoiditis, in October 1892 mastoidectomy, persistent purulence. Early in 1893 diagnosis of nephritis. Extraction of a superior tooth, punturing of the maxillary sinus, then twice radical opening of the maxillary sinus. Painful ankylosis and paralyses ending in complete immobility, hyperthermy, exitus on Jan. 1 1894.

DISCUSSION

The case history is repeated in short and discussed. At that time a diagnosis and an effective therapy were not available. Today the disease could have been kept under control applying immunosuppressive and antibiotic treatment.

摘要

摘要

海因里希·赫兹及其家人的一本日记和大量书信对他的生平进行了细致记录,阿尔布雷希特·福尔辛在1997年通过一部经过精心研究的传记将其呈现出来,这些记录让人得出结论:H. 赫兹死于韦格纳肉芽肿病,而这种疾病在45年后才得到研究。

韦格纳肉芽肿病

1936年和1939年由弗里德里希·韦格纳首次描述的肉芽肿病症状,现用作者的文字引述简要呈现如下:该病始于一场持续至最后的顽固性感冒,随后是鼻窦、耳朵、口腔和咽部黏膜受累,伴有低热、虚弱,在最后阶段会扩散至肾炎、败血症热、关节炎、肌痛、麻痹直至完全无法活动,最终死亡。病因尚未完全明了,但可能基于免疫反应。

H. 赫兹:个人履历:1857年出生于德国汉堡;中学毕业后在德累斯顿、慕尼黑和柏林接受物理学学术训练。1885年成为卡尔斯鲁厄的物理学教授,1889年起在波恩任教。1887/88年对电磁波进行探索,如今电磁波是所有无线电通信的基础,还对光电效应进行了探索,光电效应是太阳能技术的基础。获得众多高级别的荣誉。

H. 赫兹:病例史:基于从私人信件和日记中大量引用的文字详细呈现病例史。在经历了一些涉及牙齿和脚趾的常见病症后,1892年夏天全身性疾病显现出来,表现为一场顽固性感冒,直至去世,这一直是治疗的重点。多次切除鼻部的肉芽组织:无结核病,无癌症。患有中耳炎并伴有化脓性乳突炎,1892年10月进行了乳突切除术,但仍持续流脓。1893年初诊断出肾炎。拔除一颗上牙,对上颌窦进行穿刺,随后两次对上颌窦进行根治性切开。出现疼痛性关节强硬和麻痹,最终完全无法活动,高热,于1894年1月1日去世。

讨论

简要重复病例史并进行讨论。当时无法做出诊断和进行有效治疗。如今,应用免疫抑制和抗生素治疗本可控制该病。

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