Greulich W, Sackmann A, Schlichting P
Neurologische Universitätsklinik, Ruhruniversität.
Nervenarzt. 1992 Apr;63(4):228-33.
Garcin syndrome is an ipsilateral step-by-step deterioration of all 12 brain cranial nerves, first described in 1927. The underlying cause is usually a sarcoma or carcinoma of the skull base. The pathogenesis of the Garcin syndrome is chiefly determined by the slow localized growth of these tumors, rather than by their histology and primary localisation. The prognosis is as a rule unfavourable. The findings on computed and magnetic resonance tomography are important for an early diagnosis. Two cases of Garcin syndrome are reported, one of which was probably due to a tonsillar carcinoma, while the other was caused by a mucinous adenocarcinoma of the nasopharynx.
加尔辛综合征是12对脑神经同侧的逐步恶化,于1927年首次被描述。其潜在病因通常是颅底肉瘤或癌。加尔辛综合征的发病机制主要由这些肿瘤的缓慢局部生长决定,而非其组织学和原发部位。通常预后不佳。计算机断层扫描和磁共振成像的结果对早期诊断很重要。报告了两例加尔辛综合征病例,其中一例可能由扁桃体癌引起,另一例由鼻咽黏液腺癌引起。