Hayashi Yasunori, Majewska Ania K
RIKEN-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Neuron. 2005 May 19;46(4):529-32. doi: 10.1016/j.neuron.2005.05.006.
Dendritic spines are tiny protrusions on dendritic shafts where most excitatory synapses are located. Recent advances in imaging technologies have given us great insight into the function of spines as biochemical compartments. Here we review recent evidence suggesting that the geometry of dendritic spines controls postsynaptic calcium signaling and is bidirectionally regulated during synaptic plasticity.
树突棘是树突轴上的微小突起，大多数兴奋性突触都位于此处。成像技术的最新进展使我们对树突棘作为生化区室的功能有了深入了解。在此，我们综述了最近的证据，这些证据表明树突棘的几何形状控制着突触后钙信号传导，并且在突触可塑性过程中受到双向调节。
