Foxl2是卵巢分化定向所必需的。

Foxl2 is required for commitment to ovary differentiation.

作者信息

Ottolenghi Chris, Omari Shakib, Garcia-Ortiz J Elias, Uda Manuela, Crisponi Laura, Forabosco Antonino, Pilia Giuseppe, Schlessinger David

机构信息

Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.

出版信息

Hum Mol Genet. 2005 Jul 15;14(14):2053-62. doi: 10.1093/hmg/ddi210. Epub 2005 Jun 8.

DOI:10.1093/hmg/ddi210

PMID:15944199

Abstract

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.

摘要

哺乳动物中双潜能性腺向雌性性别分化的遗传控制目前还知之甚少。我们发现，缺乏叉头转录因子Foxl2的小鼠XX性腺形成减数分裂前期卵母细胞，但随后激活了体细胞睾丸决定的遗传程序。因此，关键的Foxl2作用在雌性性腺分化的几个阶段抑制了雄性基因途径。这表明性别决定基因可能在雌性整个生殖生命过程中持续参与维持卵巢功能。