头颈部皮肤鳞状细胞癌的区域转移模式

Pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck.

作者信息

Barzilai Geva, Greenberg Elhanan, Cohen-Kerem Raanan, Doweck Ilana

机构信息

Department of Otolaryngology-Head and Neck Surgery, Carmel Medical Center, Haifa, Israel.

出版信息

Otolaryngol Head Neck Surg. 2005 Jun;132(6):852-6. doi: 10.1016/j.otohns.2005.01.036.

DOI:10.1016/j.otohns.2005.01.036

PMID:15944554

Abstract

OBJECTIVE

To assess the pattern of regional metastases from SCC of the skin of the head and neck as a prognostic factor.

STUDY DESIGN AND SETTING

A retrospective chart review of 22 patients treated in a tertiary academic center.

RESULTS

Metastases could be assessed clinically in the parotid gland and the neck in 50% and 59% of the patients, respectively. Histologic examination showed metastases in the parotid gland and the neck in 68% and 45.5%, respectively. Occult disease was 36% and 20% in the parotid gland and neck, respectively. The 1st echelon for metastasis was the parotid gland lymph nodes, whereas level II lymph nodes were the 1st echelon in the neck. Metastases to both the parotid gland and neck decreased the overall survival to 0, compared with 60% for metastases to the parotid gland and 100% for the neck.

CONCLUSIONS

SCC of the skin of the head and neck with regional metastases has a high incidence of occult metastases in the parotid gland and the neck. Patients with metastases in both sites have a poor prognosis.

摘要

目的

评估头颈部皮肤鳞状细胞癌区域转移模式作为预后因素的情况。

研究设计与设置

对一家三级学术中心治疗的22例患者进行回顾性病历审查。

结果

分别有50%和59%的患者可在临床上评估腮腺和颈部的转移情况。组织学检查显示，腮腺和颈部转移的发生率分别为68%和45.5%。腮腺和颈部的隐匿性疾病分别为36%和20%。转移的第一梯队是腮腺淋巴结，而颈部的第一梯队是Ⅱ区淋巴结。与腮腺转移患者的总生存率为60%、颈部转移患者的总生存率为100%相比，腮腺和颈部均发生转移的患者总生存率降至0。