Fetal and perinatal infections. A consecutive study.

118 cases of second trimester abortions, stillbirths, and perinatal deaths together with the placentas and case records were studied histologically and microbiologically to evaluate the incidence of infection and to assess possible correlations to certain clinical parameters. The infection rate was 39.4%, highest in the second trimester abortions (58.2%), where infection was also considered the most frequent cause of death (45.5%), though mostly without maternal signs of infection. 36.6% of cases with histological inflammation exhibited positive culture results. The value of ordinary culture of the placenta and fetus is questionable, at least if not performed immediately after delivery. A significant correlation between infection and vaginal bleeding during pregnancy, ruptured membranes of more than 24 hours duration, and spontaneous labour was found. No protective effect of intact membranes was found.