Bassarova A V, Torlakovic E, Sedloev T, Hristova S L, Trifonov D V, Nesland J M
Department of Pathology, Alexander University Hospital, Medical University, Sofia, Bulgaria.
Histol Histopathol. 2005 Jul;20(3):791-9. doi: 10.14670/HH-20.791.
Family history of breast carcinoma, multicentric tumor foci in one breast, and in situ lobular carcinoma increase the risk of bilateral breast cancer (BBC), synchronous or metachronous. Synchronous tumors are designated as simultaneous breast carcinoma if they appear at the same time. The CD44 family and cadherin/catenin immunophenotype of this group of BBCs has not yet been evaluated. The aim of this study was to compare clinicopathological characteristics and immunohistochemical profiles of simultaneous BBC and corresponding lymph node metastases in eight patients.
In toto 15 primary and 9 metastatic tumors were evaluated. The expression of CD44 variant isoforms, beta-catenin, E, P and N-cadherin were evaluated by immunohistochemistry. Rare types of breast carcinoma were frequent in this group of patients. There were 6 pleomorphic lobular, 5 invasive ductal of usual type, 3 atypical medullary carcinomas, 2 mucinous and one invasive micropapillary carcinoma. The expression CD44v6 was most frequent, followed by CD44v3-10, CD44v5, and CD44v3. CD44v4 was generally not expressed. E-cadherin was expressed in 80% primary tumors, 40% expressed N-cadherin, and 66% expressed P-cadherin.
Generally, simultaneous carcinomas had different morphology and different immunophenotype. Each primary tumor was more similar to its corresponding metastatic tumor than to the contralateral primary tumor.
乳腺癌家族史、一侧乳腺内多中心肿瘤灶以及小叶原位癌会增加双侧乳腺癌（BBC）发生的风险，包括同时性或异时性的。如果同步肿瘤同时出现，则被指定为同时性乳腺癌。该组BBC的CD44家族以及钙黏蛋白/连环蛋白免疫表型尚未得到评估。本研究的目的是比较8例患者中同时性BBC及其相应淋巴结转移灶的临床病理特征和免疫组化谱。
共评估了15个原发性肿瘤和9个转移瘤。通过免疫组化评估CD44变异体亚型、β-连环蛋白、E-钙黏蛋白、P-钙黏蛋白和N-钙黏蛋白的表达。该组患者中罕见类型的乳腺癌较为常见。有6例多形性小叶癌、5例普通型浸润性导管癌、3例非典型髓样癌、2例黏液癌和1例浸润性微乳头状癌。CD44v6的表达最为常见，其次是CD44v3 - 10、CD44v5和CD44v3。CD44v4通常不表达。80%的原发性肿瘤表达E-钙黏蛋白，40%表达N-钙黏蛋白，66%表达P-钙黏蛋白。
一般来说，同时性癌具有不同的形态和不同的免疫表型。每个原发性肿瘤与其相应的转移瘤比与对侧原发性肿瘤更为相似。
