Lukl J
I interní klinika FN, Olomouc.
Cas Lek Cesk. 2005;144(4):224-7.
Last 40 years of growing knowledge of the mechanisms of cardiac arrhythmias has unambiguously demonstrated therapeutic superiority of non-pharmacological treatment over antiarrhythmic drugs, which are in these days rather used in acute phase or moderate forms of tachyarrhythmias. Diagnosis of bradyarrhythmias relies mainly on bradycardia symptoms, bradycardia detection on the surface ECG and their mutual time correlation. Electrophysiological study stands aloof in these cases. Permanent cardiac stimulation dominates unequivocally in the therapy of bradyarrhythmias. Electrophysiological study has taken a unique place in the tachycardia therapy, since it allows inducing reproducibly tachyarrhythmia and by means of its mapping to determine its course. Thus, a completely new, "intracardiac" view on the arrhythmia mechanism has evolved and considerably weakened the diagnostic importance of the surface ECG. Radiofrequency catheter ablations represent a rapidly evolving causal therapeutic modality of tachyarrhythmias, especially in the absence of structural heart disease. Significantly decreased left ventricular ejection fraction combined with tachycardia symptoms should raise suspicion of life threatening ventricular arrhythmias, which are nowadays successfully treated by implantation of a cardioverter-defibrillator.
在过去40年中,对心律失常机制的认识不断深入,这明确显示了非药物治疗相对于抗心律失常药物的治疗优势,如今抗心律失常药物多用于快速性心律失常的急性期或中度形式。缓慢性心律失常的诊断主要依赖于心动过缓症状、体表心电图上心动过缓的检测及其相互间的时间相关性。在这些情况下,电生理研究作用不大。永久性心脏起搏在缓慢性心律失常的治疗中无疑占据主导地位。电生理研究在快速性心律失常的治疗中占据独特地位,因为它能够可重复地诱发快速性心律失常,并通过标测确定其发生过程。因此,一种全新的、“心内”的心律失常机制观点得以形成,这大大削弱了体表心电图的诊断重要性。射频导管消融术是快速性心律失常迅速发展的一种病因治疗方式,尤其是在无结构性心脏病的情况下。左心室射血分数显著降低并伴有心动过速症状,应怀疑存在危及生命的室性心律失常,如今通过植入心脏复律除颤器可成功治疗此类心律失常。