Schmidt P J, Ezri M D, Denes P
Dis Mon. 1987 Jul;33(7):365-432.
Arrhythmias may result from abnormalities of impulse initiation (automaticity), conduction (slow conduction, block, reentry), or a combination. The central and peripheral nervous systems have an important influence on the genesis of cardiac arrhythmias. Sympathetic and parasympathetic fibers innervate both atria and ventricle. The study of clinical cardiac arrhythmias includes the use of invasive and noninvasive testing procedures. The ECG, ambulatory monitoring, esophageal recording, exercise testing, and signal averaging techniques are the currently used noninvasive tests. Intracardiac electrophysiologic studies and endocardial catheter mapping are invasive techniques. The treatment of cardiac arrhythmias includes the use of antiarrhythmic drugs, cardiac pacing (antibradycardia, antitachycardia), implantable automatic defibrillator, cardiac fulguration, and antitachycardiac surgery. Clinical cardiac arrhythmias are of two types, the bradyarrhythmias and the tachyarrhythmias. The tachyarrhythmia, in turn, may be supraventricular or ventricular. There are clinical syndromes specifically related to arrhythmias: preexcitation syndromes are associated with supraventricular tachyarrhythmias, long Q-T syndromes with ventricular tachyarrhythmias, and sick sinus syndrome with bradyarrhythmias. The "tachycardia-bradycardia syndrome" is a combination of atrial tachyarrhythmias and sinus node dysfunction (some of the patients may also have ventricular tachyarrhythmias). Specific arrhythmias are recognized by their ECG characteristics. These arrhythmias also have specific electrophysiologic features which can be defined during invasive electrophysiologic studies. Cardiac arrhythmias may or may not be accompanied by underlying organic heart disease. Their treatment is related to the specific diagnosis and mechanism of the rhythm disturbance. The presence and extent of underlying organic heart disease is an important factor in the selection of antiarrhythmic therapy (drug, pacemaker, or surgery).
心律失常可能由冲动起始异常(自律性)、传导异常(传导缓慢、阻滞、折返)或两者兼而有之引起。中枢和外周神经系统对心律失常的发生具有重要影响。交感神经和副交感神经纤维支配心房和心室。临床心律失常的研究包括使用侵入性和非侵入性检测程序。心电图、动态监测、食管记录、运动试验和信号平均技术是目前使用的非侵入性检查。心内电生理研究和心内膜导管标测是侵入性技术。心律失常的治疗包括使用抗心律失常药物、心脏起搏(抗心动过缓、抗心动过速)、植入式自动除颤器、心脏电灼和抗心动过速手术。临床心律失常分为两种类型,即缓慢性心律失常和快速性心律失常。快速性心律失常又可分为室上性和室性。有一些临床综合征与心律失常特别相关:预激综合征与室上性快速性心律失常有关,长Q-T综合征与室性快速性心律失常有关,病态窦房结综合征与缓慢性心律失常有关。“心动过速-心动过缓综合征”是房性快速性心律失常和窦房结功能障碍的组合(一些患者也可能有室性快速性心律失常)。特定的心律失常可通过其心电图特征来识别。这些心律失常也具有特定的电生理特征,可在侵入性电生理研究中确定。心律失常可能伴有或不伴有潜在的器质性心脏病。其治疗与心律失常的具体诊断和机制有关。潜在器质性心脏病的存在和程度是选择抗心律失常治疗(药物、起搏器或手术)的重要因素。