Sergeev A N, P'iankov O V, Shishkina L N, Duben' L G, Petrishchenko V A, Zhukov V A, P'iankova O G, Sviatchenko L I, Sherstoboev E Iu, Karimova T V, Martiushev-Poklad A V, Sergeeva S A, Epshteĭn O I, Glotov A G, Glotova T I
Antibiot Khimioter. 2004;49(11):7-11.
Course intragastric administration of ultralow doses of human gamma-interferon antibodies (ULD anti-IFN-gamma) to intact mice resulted in an increase of endogenous IFN-gamma production by the animal lymphocytes. Oral prophylactic administration of ULD anti-IFN-gamma significantly lowered the influenza virus concentration in the animal lungs at the initial stage of the aerogenous infection: in 2 (p = 0.05) and 3 (p = 0.07) days after the contamination. The therapeutic antiviral effect of ULD anti-IFN-gamma in mice with influenza was evident from a significant decrease of the influenza virus concentration in the lungs of the animals on the 4th (p = 0.05) and 5th (p = 0.07) days after the contamination. The antiviral effect of ULD anti-IFN-gamma after the prophylactic and therapeutic use is likely provided by induction of endogenous IFN-gamma.
对未受损伤的小鼠进行超低剂量人γ-干扰素抗体（ULD抗IFN-γ）的胃内给药，会导致动物淋巴细胞内源性IFN-γ产生增加。口服预防性给予ULD抗IFN-γ能在空气传播感染初期显著降低动物肺部的流感病毒浓度：在感染后2天（p = 0.05）和3天（p = 0.07）。ULD抗IFN-γ对感染流感小鼠的治疗性抗病毒作用在感染后第4天（p = 0.05）和第5天（p = 0.07）动物肺部流感病毒浓度显著降低中明显体现。预防性和治疗性使用后，ULD抗IFN-γ的抗病毒作用可能是由内源性IFN-γ的诱导所致。
