Tanaka Hironori, Iwasaki Yoshiaki, Nouso Kazuhiro, Kobayashi Yoshiyuki, Nakamura Shin-Ichiro, Matsumoto Eiji, Toshikuni Nobuyuki, Kaneyoshi Toshihiko, Ohsawa Toshiya, Takaguchi Kouichi, Fujio Kozo, Senoh Tomonori, Ohnishi Tohru, Sakaguchi Kohsaku, Shiratori Yasushi
Department of Gastroenterology, Hepatology and Infectious Disease, Okayama University School of Medicine, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
J Gastroenterol Hepatol. 2005 Jun;20(6):850-6. doi: 10.1111/j.1440-1746.2005.03823.x.
The prevalence of prior hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients and its role in hepatocarcinogenesis are not clear. The aim of the present study is to clarify the importance of prior HBV infection in development of HCC.
Of 1288 consecutive HCC patients between January 1999 and October 2002, 1008 patients were enrolled. To determine the influence of prior HBV infection in hepatitis B surface antigen (HBsAg)-negative HCC, the prevalence of antibody to hepatitis B core antigen (anti-HBc) was examined according to age, and the clinical features were compared between the anti-HBc positive and the negative groups.
The proportion of HBsAg-negative HCC patients, HCC patients with antibody to hepatitis C virus (anti-HCV; C-HCC) and HCC patients negative for both HBsAg and anti-HCV (nBnC-HCC), increased with age. The anti-HBc-positive rates in C-HCC patients also increased with age. Those rates in nBnC-HCC patients were >50% in all age groups. Furthermore, it was found that the anti-HBc-positive rates of these patients were higher than those of corresponding control patients. Tumor size and a positive rate for vessel involvement both in C-HCC and nBnC-HCC patients were larger and higher, respectively, in anti-HBc-positive patients compared with anti-HBc-negative patients, although the difference in nBnC-HCC did not reach statistical significance because of the small numbers. These tumor characteristics were similar to those of B-HCC patients.
A possible contribution of prior HBV infection to the development of HCC is indicated.
肝细胞癌（HCC）患者既往感染乙型肝炎病毒（HBV）的患病率及其在肝癌发生中的作用尚不清楚。本研究的目的是阐明既往HBV感染在HCC发生中的重要性。
在1999年1月至2002年10月期间连续收治的1288例HCC患者中，纳入了1008例患者。为了确定既往HBV感染对乙型肝炎表面抗原（HBsAg）阴性HCC的影响，根据年龄检测乙型肝炎核心抗体（抗-HBc）的患病率，并比较抗-HBc阳性组和阴性组的临床特征。
HBsAg阴性HCC患者、丙型肝炎病毒抗体（抗-HCV；C-HCC）阳性HCC患者和HBsAg及抗-HCV均阴性的HCC患者（nBnC-HCC）的比例随年龄增加而升高。C-HCC患者的抗-HBc阳性率也随年龄增加。nBnC-HCC患者在所有年龄组中的抗-HBc阳性率均>50%。此外，发现这些患者的抗-HBc阳性率高于相应对照组患者。与抗-HBc阴性患者相比，抗-HBc阳性的C-HCC和nBnC-HCC患者的肿瘤大小和血管侵犯阳性率分别更高和更高，尽管由于数量较少，nBnC-HCC患者的差异未达到统计学意义。这些肿瘤特征与B-HCC患者相似。
提示既往HBV感染可能对HCC的发生有一定作用。
