Park N H, Song I H, Chung Y-H
Division of Gastroenterology, Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Centre, Seoul, Korea.
Postgrad Med J. 2006 Aug;82(970):507-15. doi: 10.1136/pgmj.2006.047431.
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and has a wide geographical variation. Eighty per cent of HCC is attributed to hepatitis B virus (HBV). The predominant carcinogenic mechanism of HBV associated HCC is through the process of liver cirrhosis, but direct oncogenic effects of HBV may also contribute. Prevention of HBV infections as well as effective treatment of chronic hepatitis B is still needed for the global control of HBV associated HCC. Continued investigation of the mechanisms of hepatocarcinogenesis will refine our current understanding of the molecular and cellular basis for neoplastic transformation in the liver.
肝细胞癌（HCC）是全球第五大常见癌症，且存在广泛的地域差异。80%的HCC归因于乙型肝炎病毒（HBV）。HBV相关HCC的主要致癌机制是通过肝硬化过程，但HBV的直接致癌作用也可能起作用。为了全球控制HBV相关HCC，仍需要预防HBV感染以及有效治疗慢性乙型肝炎。对肝癌发生机制的持续研究将完善我们目前对肝脏肿瘤转化的分子和细胞基础的理解。
