Mizushima Takaaki, Sawa Kiminari, Ochi Koji, Tanioka Hiroaki, Wakuta Akiko, Matsushita Koki, Shirahige Akinori, Kiura Katsuyuki, Tanimoto Mitsune, Koide Norio, Harada Hideo
Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan.
J Gastroenterol Hepatol. 2005 Jun;20(6):910-4. doi: 10.1111/j.1440-1746.2005.03827.x.
Disorders of the motor function of the upper gastrointestinal tract have been implicated in the pathogenesis of non-ulcer dyspepsia. Approximately 50% of patients with abdominal symptoms (without ulcer) have normal gastric emptying. Apart from gastric emptying, other mechanisms are very important in the etiology of non-ulcer dyspepsia.
Gastric emptying and gallbladder motility were simultaneously investigated in 16 patients with non-ulcer dyspepsia and in 15 healthy controls. Fasting blood samples were taken, and pepsinogen levels were assayed.
Gastric emptying time, fasting antral diameter, and post-prandial antral diameter were not significantly different between the patients with non-ulcer dyspepsia and the controls. Fasting gallbladder volume, the time required to reach minimal gallbladder residual volume, minimal gallbladder residual volume, and the serum levels of pepsinogen were not significantly different. Simple linear regression was used to summarize the relationship between gastric emptying time and time required to reach minimal gallbladder residual volume. In the controls, the gastric emptying time and time required to reach minimal gallbladder residual volume were linearly related. However, in the patients with non-ulcer dyspepsia, they were not related.
These observations suggest that disturbance of coordination between gastric emptying and gallbladder emptying is a cause of the symptoms of non-ulcer dyspepsia.
上消化道运动功能紊乱与非溃疡性消化不良的发病机制有关。约50%有腹部症状（无溃疡）的患者胃排空正常。除胃排空外，其他机制在非溃疡性消化不良的病因中也非常重要。
对16例非溃疡性消化不良患者和15例健康对照者同时进行胃排空和胆囊运动功能的研究。采集空腹血样并检测胃蛋白酶原水平。
非溃疡性消化不良患者与对照组的胃排空时间、空腹胃窦直径和餐后胃窦直径无显著差异。空腹胆囊容积、达到最小胆囊残余容积所需时间、最小胆囊残余容积以及胃蛋白酶原血清水平无显著差异。采用简单线性回归分析胃排空时间与达到最小胆囊残余容积所需时间之间的关系。在对照组中，胃排空时间与达到最小胆囊残余容积所需时间呈线性相关。然而，在非溃疡性消化不良患者中，二者无相关性。
这些观察结果提示，胃排空与胆囊排空之间协调性的紊乱是导致非溃疡性消化不良症状的原因之一。
