低剂量雷贝拉唑、阿莫西林和甲硝唑三联疗法治疗中国患者幽门螺杆菌感染

Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients.

作者信息

Wong Wai Man, Huang Jiaqing, Xia Harry H X, Fung Fiona M Y, Tong Teresa S M, Cheung Kess L, Ho Vicky Y K, Lai Kam Chuen, Chan Chi Kuen, Chan Annie O O, Hui Chee-Kin, Lam Shiu Kum, Wong Benjamin C Y

机构信息

Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong.

出版信息

J Gastroenterol Hepatol. 2005 Jun;20(6):935-40. doi: 10.1111/j.1440-1746.2005.03889.x.

DOI:10.1111/j.1440-1746.2005.03889.x

PMID:15946144

Abstract

BACKGROUND

Rabeprazole in combination with amoxicillin and metronidazole (RAM) has been shown to be an effective second-line treatment of Helicobacter pylori infection. The effects were compared of 7-day low-dose and high dose rabeprazole in RAM for the primary treatment of H. pylori infection in Chinese patients.

METHODS

Helicobacter pylori-positive dyspeptic patients were randomized to receive either (i) rabeprazole 10 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-10) or (ii) high-dose rabeprazole 20 mg, amoxicillin 1000 mg and metronidazole 400 mg (RAM-20), each given twice daily for 7 days. Helicobacter pylori eradication was confirmed by (13)c-urea breath test 5 weeks after stopping medications. side-effects of treatments were documented.

RESULTS

A total of 120 patients were eligible for analysis. By intention-to-treat and per-protocol analysis, the eradication rates were 83% and 86% in the RAM-10 group and 75% and 76% in the RAM-20 group, respectively (P = 0.26 and P = 0.17). Both regimens were well-tolerated and compliance was >98% in both groups.

CONCLUSIONS

Low-dose rabeprazole in combination with amoxicillin and metronidazole is an effective, economical and well-tolerated therapy for the treatment of H. pylori infection in Chinese population.

摘要

背景

雷贝拉唑联合阿莫西林和甲硝唑（RAM）已被证明是治疗幽门螺杆菌感染的一种有效的二线治疗方案。比较了7天低剂量和高剂量雷贝拉唑在RAM方案中对中国患者幽门螺杆菌感染的初始治疗效果。

方法

幽门螺杆菌阳性的消化不良患者被随机分为两组，分别接受：（i）雷贝拉唑10mg、阿莫西林1000mg和甲硝唑400mg（RAM-10），或（ii）高剂量雷贝拉唑20mg、阿莫西林1000mg和甲硝唑400mg（RAM-20），均每日两次，共7天。停药5周后通过13C-尿素呼气试验确认幽门螺杆菌根除情况。记录治疗的副作用。