丝虫线虫分泌产物ES-62颠覆免疫反应的潜在信号传导机制。
Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.
作者信息
Goodridge Helen S, Stepek Gillian, Harnett William, Harnett Margaret M
机构信息
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK.
出版信息
Immunology. 2005 Jul;115(3):296-304. doi: 10.1111/j.1365-2567.2005.02167.x.
Abstract
Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod-transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory-secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects.
摘要
分泌免疫调节分子是病原体在宿主生物体中生存所采用的关键策略。例如，通过抑制和调节宿主免疫反应在受感染宿主体内实现长寿的节肢动物传播的丝虫线虫会产生排泄-分泌（ES）产物，这些产物已被证明具有免疫调节特性。在这篇综述中，我们讨论了含磷酸胆碱的丝虫线虫分泌糖蛋白ES-62的免疫调节作用，并描述了其为实现这些作用所靶向的细胞内信号转导途径。
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