Torkildsen Oivind, Utsi Egil, Mellgren Svein Ivar, Harbo Hanne F, Vedeler Christian A, Myhr Kjell-Morten
The Multiple Sclerosis National Competence Centre, Haukeland University Hospital, University of Bergen, N-5021 Bergen, Norway.
Immunology. 2005 Jul;115(3):416-21. doi: 10.1111/j.1365-2567.2005.02158.x.
Receptors for the Fc domain of IgG (Fc gammaR) play a critical role in linking cellular and humoral immunity. The various Fc gammaR genotypes may contribute to differences in infectious and immune-related diseases in various ethnic populations. The Samis are the aboriginal inhabitants of Norway and Fennoscandinavia and differ ethnically from the Norwegians. The distribution of various immune-related diseases has been reported to differ between Sami and Norwegians. This is the first study to evaluate the distribution of Fc gammaR polymorphisms in a Sami population. Two hundred Samis were genotyped for polymorphisms in the Fc gammaRIIA, Fc gammaRIIIA and Fc gammaRIIIB genes. The genotype and allele frequencies were compared with those of 272 healthy Norwegians. The Sami and Norwegian Fc gammaRIIA, Fc gammaRIIIA and Fc gammaRIIIB genotypes differed significantly. The Samis had higher frequencies of the Fc gammaRIIa-H/H131, Fc gammaRIIIa-F/F158 and Fc gammaRIIIb-NA1/NA1 genotypes. The Fc gammaR genotypes were non-randomly distributed in both populations. These findings may be important for the prevalence of autoimmune and infectious diseases in the two populations.
免疫球蛋白G（IgG）Fc段受体（FcγR）在连接细胞免疫和体液免疫方面发挥着关键作用。不同的FcγR基因型可能导致不同种族人群在感染性疾病和免疫相关疾病方面存在差异。萨米人是挪威和芬兰斯堪的纳维亚半岛的原住民，在种族上与挪威人不同。据报道，萨米人和挪威人在各种免疫相关疾病的分布上存在差异。这是第一项评估萨米人群中FcγR多态性分布的研究。对200名萨米人进行了FcγRIIA、FcγRIIIA和FcγRIIIB基因多态性的基因分型。将基因型和等位基因频率与272名健康挪威人的进行了比较。萨米人和挪威人的FcγRIIA、FcγRIIIA和FcγRIIIB基因型存在显著差异。萨米人中FcγRIIa-H/H131、FcγRIIIa-F/F158和FcγRIIIb-NA1/NA1基因型的频率较高。FcγR基因型在这两个人群中均呈非随机分布。这些发现可能对这两个人群中自身免疫性疾病和感染性疾病的患病率具有重要意义。
