Pawlik A, Carlsson L, Meisel P, Czaja-Bulsa G, Mokrzycka M, Gawrońska-Szklarz B
Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland. pawand.poczta.onet.pl
Int Arch Allergy Immunol. 2004 Mar;133(3):233-8. doi: 10.1159/000076829. Epub 2004 Feb 16.
Fcgamma receptor II (FcgammaRIIa) is the most widely distributed of the classes of FcR and is expressed in polymorphic forms on most types of hematopoietic cells. Recent data suggest that this polymorphism may be relevant to FcgammaRIIa function. This might be linked to variability in immune response and therefore related to the pathogenesis of atopic diseases. The aim of the study was to evaluate the FcgammaRIIa polymorphism in children with atopic diseases.
In the study were included 140 atopic children, 77 with food allergy and 126 healthy subjects as the control group. The FcgammaRIIa polymorphism was determined using the polymerase chain reaction method.
The distribution of FcgammaRIIa genotypes in atopic children did not differ from that of healthy controls. Moreover, there was no association between the FcgammaRIIa genotypes and atopic diseases.
It seems that the FcgammaRIIa polymorphism does not represent an important genetic risk factor for atopic diseases susceptibility.
Fcγ受体II（FcγRIIa）是FcR类别中分布最广泛的，以多态性形式表达于大多数类型的造血细胞上。近期数据表明，这种多态性可能与FcγRIIa功能相关。这可能与免疫反应的变异性有关，因此与特应性疾病的发病机制相关。本研究的目的是评估患有特应性疾病儿童的FcγRIIa多态性。
本研究纳入了140名患有特应性疾病的儿童，其中77名患有食物过敏，以及126名健康受试者作为对照组。使用聚合酶链反应方法测定FcγRIIa多态性。
患有特应性疾病儿童的FcγRIIa基因型分布与健康对照组并无差异。此外，FcγRIIa基因型与特应性疾病之间没有关联。
FcγRIIa多态性似乎并非特应性疾病易感性的重要遗传危险因素。
