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癌症自我缓解与肿瘤稳定性——一种随机方法。

Cancer self remission and tumor stability-- a stochastic approach.

作者信息

Sarkar Ram Rup, Banerjee Sandip

机构信息

Embryology Research Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata 700 108, India.

出版信息

Math Biosci. 2005 Jul;196(1):65-81. doi: 10.1016/j.mbs.2005.04.001.

Abstract

The paper aims to express the spontaneous regression and progression of a malignant tumor system as a prey--predator like system. The model is a three dimensional deterministic system, consisting of tumor cells, hunting predator cells and resting predator cells. Local stability analysis is performed along with numerical simulations to support the analytical findings. Moreover, the deterministic model is extended to a stochastic one allowing random fluctuations around the positive interior equilibrium. The stochastic stability properties of the model are investigated both analytically and numerically. The thresholds obtained from our study may be helpful to control the malignant tumor growth.

摘要

本文旨在将恶性肿瘤系统的自发消退和进展表述为一个类似捕食者 - 猎物的系统。该模型是一个三维确定性系统,由肿瘤细胞、活跃的捕食细胞和静止的捕食细胞组成。进行了局部稳定性分析并结合数值模拟以支持分析结果。此外,确定性模型被扩展为一个随机模型,允许在正内部平衡点周围存在随机波动。对该模型的随机稳定性特性进行了分析和数值研究。我们研究中获得的阈值可能有助于控制恶性肿瘤的生长。

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