聚乳酸-聚乙二醇-聚乳酸三嵌段共聚物的胶束状纳米颗粒作为化疗载体
Micelle-like nanoparticles of PLA-PEG-PLA triblock copolymer as chemotherapeutic carrier.
作者信息
Venkatraman Subbu S, Jie Pan, Min Feng, Freddy Boey Yin Chiang, Leong-Huat Gan
机构信息
School of Materials Science and Engineering, N4.1-1-30 Nanyang Avenue, Nanyang Technological University, Singapore 639798, Singapore.
出版信息
Int J Pharm. 2005 Jul 14;298(1):219-32. doi: 10.1016/j.ijpharm.2005.03.023.
Triblock copolymer PLA-PEG-PLA were synthesized using ring opening polymerization with different LA/EG ratio. Micellar aggregates were prepared from these block copolymers and characterized. The degradation characteristics of selected copolymers were assessed in both micellar and film forms. Surface segregation of PEG was also quantified as a function of copolymer composition. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanospheres with good efficiency. The drug release profile showed good control over the release of paclitaxel from these polymers.
使用开环聚合法，以不同的乳酸（LA）/乙二醇（EG）比例合成了三嵌段共聚物聚乳酸-聚乙二醇-聚乳酸（PLA-PEG-PLA）。由这些嵌段共聚物制备了胶束聚集体并进行了表征。对所选共聚物在胶束和薄膜形式下的降解特性进行了评估。还根据共聚物组成对聚乙二醇（PEG）的表面偏析进行了量化。将抗癌药物5-氟尿嘧啶（5-FU）和紫杉醇负载到胶束纳米球中，负载效率良好。药物释放曲线显示对这些聚合物中紫杉醇的释放具有良好的控制。
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