Zhang Zhenjiang, King Michael R
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235 USA.
Cell Mol Bioeng. 2017;10(4):275-294. doi: 10.1007/s12195-017-0497-4. Epub 2017 Jul 20.
Circulating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and isolate them with high efficiency. Nanomaterials, with unique structural and functional properties, have shown strong promise to meet the challenging demands. In this review, we discuss CTC capture and therapeutic targeting, emphasizing the significance of the nanomaterials being used for this purpose. The next generation of therapy for metastatic cancer may well involve capturing and even directly neutralizing CTCs using nanomaterials.
循环肿瘤细胞是癌症转移的一个标志，癌症转移导致了约90%的癌症相关死亡。它们的检测和特征分析在癌症生物学和临床实践中具有重要意义。然而，循环肿瘤细胞是罕见细胞，由异质性亚群组成，需要高度灵敏和特异的技术来高效地识别和分离它们。具有独特结构和功能特性的纳米材料已显示出有望满足这些具有挑战性的需求。在本综述中，我们讨论了循环肿瘤细胞的捕获和治疗靶向，强调了为此目的使用纳米材料的重要性。转移性癌症的下一代治疗很可能涉及使用纳米材料捕获甚至直接中和循环肿瘤细胞。
