Passos Valéria Maria de Azeredo, Barreto Sandhi Maria, Diniz Leonardo Maurício, Lima-Costa Maria Fernanda
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Alfredo Balena 190, Belo Horizonte, Minas Gerais, Brazil.
Sao Paulo Med J. 2005 Mar 2;123(2):66-71. doi: 10.1590/s1516-31802005000200007. Epub 2005 Jun 8.
Diabetes is an increasing cause of death in developing countries. Our objective was to describe the prevalence and clinical factors associated with diabetes and impaired fasting glycemia among adults (18-59 years) and elderly adults (60+ years).
Population based, cross-sectional study in Bambuí, Brazil.
816 adult and 1,494 elderly participants were interviewed; weight, height and blood pressure measured; and blood samples collected. Diabetes was defined as plasma fasting glucose > 126 mg/dl and/or use of hypoglycemic agents; impaired fasting glycemia as glycemia of 110-125 mg/dl. Associations were investigated using multinomial logistical regression (reference: fasting glycemia < 109 mg/dl).
Among the elderly, 218 (14.59%) presented diabetes and 199 (13.32%) impaired fasting glycemia, whereas adult prevalences were 2.33% and 5.64%. After multinomial analysis, diabetes remained associated, for adults, with increased waist-to-hip ratio and total cholesterol > 240 mg/dl; for elderly adults, with family history of diabetes, body-mass index of 25-29 kg/m(2), body-mass index > 30 kg/m(2), increased waist-to-hip ratio, low HDL-cholesterol triglyceridemia of 200-499 mg/dl and triglyceridemia > 500 mg/dl. Among adults, impaired fasting glycemia remained associated negatively with male sex and positively with ages of 40-59 years, physical inactivity and increased waist-to-hip ratio; among the elderly, with alcohol consumption, overweight, obesity and triglycerides > 200 mg/dl.
The results reinforce the importance of interventions to reduce physical inactivity, alcohol consumption, obesity and dyslipidemia, so as to prevent increasing incidence of diabetes.
在发展中国家,糖尿病正成为日益严重的致死原因。我们的目的是描述成人(18 - 59岁)和老年人(60岁及以上)中糖尿病及空腹血糖受损的患病率和相关临床因素。
基于人群的横断面研究,在巴西的班布伊进行。
对816名成年人和1494名老年人进行了访谈;测量了体重、身高和血压;采集了血样。糖尿病定义为空腹血浆葡萄糖>126mg/dl和/或使用降糖药物;空腹血糖受损定义为血糖水平在110 - 125mg/dl之间。采用多项逻辑回归分析相关性(参考:空腹血糖<109mg/dl)。
在老年人中,218人(14.59%)患有糖尿病,199人(13.32%)空腹血糖受损,而成年人中的患病率分别为2.33%和5.64%。经过多项分析,对于成年人,糖尿病仍与腰臀比增加和总胆固醇>240mg/dl相关;对于老年人,糖尿病与糖尿病家族史、体重指数为25 - 29kg/m²、体重指数>30kg/m²、腰臀比增加、高密度脂蛋白胆固醇低、甘油三酯水平在200 - 499mg/dl以及甘油三酯>500mg/dl相关。在成年人中,空腹血糖受损仍与男性性别呈负相关,与40 - 59岁年龄、缺乏身体活动和腰臀比增加呈正相关;在老年人中,与饮酒、超重、肥胖和甘油三酯>200mg/dl相关。
研究结果强化了采取干预措施减少身体活动不足、饮酒、肥胖和血脂异常的重要性,以预防糖尿病发病率的上升。