Davies Justine I, Witham Miles D, Struthers Allan D
Department of Clinical Pharmacology, Division of Medicine, Dundee, Scotland, DD1 9SY.
Heart Fail Rev. 2005 Jan;10(1):63-9. doi: 10.1007/s10741-005-2350-4.
Neurohormonal dysfunction is an important and potentially modifiable part of the disease process of heart failure. In this review we will discuss the ways in which the autonomic system is deranged in congestive cardiac failure and the different ways we have of monitoring these abnormalities i.e.: heart rate variability, plasma norephinephrine activity, MIBG scanning, heart rate turbulence, baroreceptor function and briefly, microneurographic techniques and QT interval analysis. We will then discuss the direct effects of aldosterone and of aldosterone blockade on some of these parameters. We conclude that neurohormonal dysfunction is an important component of chronic heart failure, which is affected by aldosterone and can be modified by the use of aldosterone receptor blockade.
神经激素功能障碍是心力衰竭疾病进程中的一个重要且可能可改变的部分。在本综述中，我们将讨论自主神经系统在充血性心力衰竭中紊乱的方式，以及我们监测这些异常的不同方法，即：心率变异性、血浆去甲肾上腺素活性、间碘苄胍扫描、心率震荡、压力感受器功能，简要介绍微神经图技术和QT间期分析。然后我们将讨论醛固酮及其阻断对其中一些参数的直接影响。我们得出结论，神经激素功能障碍是慢性心力衰竭的一个重要组成部分，它受醛固酮影响，并且可以通过使用醛固酮受体阻滞剂来改变。
