Rutkove Seward B, Esper Gregory J, Lee Kyungmouk S, Aaron Ronald, Shiffman Carl A
Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Muscle Nerve. 2005 Sep;32(3):335-41. doi: 10.1002/mus.20377.
Electrical impedance myography (EIM) is a new bioimpedance-based technique for neuromuscular disease assessment. Past work has focused on EIM in the evaluation of diffuse diseases (such as myopathy). In this study, the method's most basic form, linear-EIM, was used for the assessment of restricted radiculopathic disease. Ten normal subjects and 10 patients with unilateral cervical or lumbosacral radiculopathy, diagnosed by electromyography and clinical criteria, were enrolled. Linear-EIM was performed bilaterally on all individuals, and comparisons with the major outcome variable, theta(avg), were made. In normal subjects, side-to-side differences in theta(avg) averaged 0.64% and were no greater than 15.9% in magnitude. In the 10 patients with radiculopathy, theta(avg)was consistently lower in the affected extremity, with a mean side-to-side difference of 15.3%, but ranging as low as 72.3%; there was a tendency for muscles with more prominent chronic neurogenic change to show greater relative reductions in theta(avg). These findings support the potential utility of EIM in assessment of localized neuromuscular disease.
电阻抗肌电图（EIM）是一种基于生物阻抗的用于评估神经肌肉疾病的新技术。过去的研究主要集中在EIM对弥漫性疾病（如肌病）的评估上。在本研究中，该方法最基本的形式，即线性EIM，被用于评估局限性神经根病。纳入了10名正常受试者和10名经肌电图和临床标准诊断为单侧颈神经根病或腰骶神经根病的患者。对所有个体双侧进行线性EIM检查，并与主要结局变量theta(avg)进行比较。在正常受试者中，theta(avg)的左右侧差异平均为0.64%，绝对值不超过15.9%。在10例神经根病患者中，患侧肢体的theta(avg)始终较低，平均左右侧差异为15.3%，但最低可达72.3%；慢性神经源性改变更明显的肌肉，其theta(avg)的相对降低往往更大。这些发现支持了EIM在评估局限性神经肌肉疾病方面的潜在应用价值。
