Liu Zheng-Wen, Zhang Ni, Han Qun-Ying, Zeng Jun-Tao, Chu Yong-Lie, Qiu Jian-Ming, Wang Ya-Wen, Ma Lie-Ting, Wang Xiao-Qin
Department of Infectious Diseases, First Hospital, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
World J Gastroenterol. 2005 Jun 14;11(22):3357-62. doi: 10.3748/wjg.v11.i22.3357.
To determine serum leptin levels and investigate their correlations with anthropometric and metabolic parameters and biochemical liver function in patients with chronic hepatitis C virus (HCV) infection and their potential clinical implications.
Forty-two chronic HCV-infected patients without anti-viral treatment were enrolled in this study, 30 patients had chronic hepatitis C, 10 had cirrhosis, and 2 had hepatocellular carcinoma (HCC). Thirty age- and sex-matched healthy individuals served as controls. Serum leptin levels were determined by ELISA. The biochemical liver function and serum lipids were determined at the same time. The height and body weight of patients and controls were measured, and body mass index (BMI) and body fat were calculated simultaneously. The correlations of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function were assessed statistically.
The mean of serum leptin levels in patients with chronic hepatitis C, HCV-associated cirrhosis, HCV-associated HCC and control groups was (6.13+/-3.94), (5.25+/-4.21), (4.17+/-0.28), and (3.59+/-3.44) ng/mL, respectively. The serum leptin level in patients with chronic hepatitis C was significantly higher than that in controls. The serum leptin levels between cirrhotic patients and controls and between male and female cirrhotic patients had no significant difference. Serum leptin levels were positively-correlated with body fat, BMI, and apolipoprotein B (Apo B) in patients with chronic HCV infection. The serum alanine aminotransferase (ALT) levels were closely-correlated with BMI in patients with chronic hepatitis C.
HCV infection interferes with fat and lipid metabolism in patients with chronic HCV infection and leptin may play a role in hepatosteatosis.
测定慢性丙型肝炎病毒（HCV）感染患者的血清瘦素水平，研究其与人体测量学、代谢参数及生化肝功能的相关性及其潜在临床意义。
本研究纳入42例未经抗病毒治疗的慢性HCV感染患者，其中30例为慢性丙型肝炎患者，10例为肝硬化患者，2例为肝细胞癌（HCC）患者。30例年龄和性别匹配的健康个体作为对照。采用酶联免疫吸附测定法（ELISA）测定血清瘦素水平。同时测定生化肝功能和血脂。测量患者和对照的身高和体重，并同时计算体重指数（BMI）和体脂。统计学评估血清瘦素水平与人体测量学、代谢参数及生化肝功能的相关性。
慢性丙型肝炎患者、HCV相关肝硬化患者、HCV相关HCC患者及对照组的血清瘦素水平均值分别为（6.13±3.94）、（5.25±4.21）、（4.17±0.28）和（3.59±3.44）ng/mL。慢性丙型肝炎患者的血清瘦素水平显著高于对照组。肝硬化患者与对照组之间以及男性和女性肝硬化患者之间的血清瘦素水平无显著差异。慢性HCV感染患者的血清瘦素水平与体脂、BMI和载脂蛋白B（Apo B）呈正相关。慢性丙型肝炎患者的血清丙氨酸氨基转移酶（ALT）水平与BMI密切相关。
HCV感染干扰慢性HCV感染患者的脂肪和脂质代谢，瘦素可能在肝脂肪变性中起作用。
