Si Jian-Min, Cao Qian, Wu Jia-Guo
Gastroenterology Laboratory, Institute of Clinical Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
World J Gastroenterol. 2005 Jun 14;11(22):3461-4. doi: 10.3748/wjg.v11.i22.3461.
To evaluate the quality of gastric ulcer healing after different antiulcer treatment by endoscopic ultrasonography (EUS).
The patients were divided into three groups, and received lansoprazole, amoxicillin and clarithromycin for 1 wk. Then group A took lansoprazole combined with tepreton for 5 wk, group B took lansoprazole and group C took tepreton for 5 wk. Endoscopy and EUS were performed before and 6 wk after medication.
There was no significant difference in cumulative healing rate to S stage between the groups (89%, 82% vs 83%, P>0.05). The rate of white scar formation was significantly higher in group A than in groups B and C (67%, 36%, 50%, P<0.05). The average contraction rates of the width of ulcer crater, length of disrupted muscularis propria layer and hypoechoic area were higher in group A than in groups B and C (0.792+/-0.090, 0.660+/-0.105 vs 0.668+/-0.143, P<0.05). The hypoechoic area disappeared in four cases of group A, one of group B and two of group C. The percentage of hypoechoic area disappearance was higher in group A than in the other two groups (44%, 9% vs 17%, P<0.05). Gastric ulcer healing was better in group A.
The combined administration of proton-pump inhibitors and mucosal protective agent can improve gastric ulcer healing.
通过内镜超声检查（EUS）评估不同抗溃疡治疗后胃溃疡愈合的质量。
将患者分为三组，接受兰索拉唑、阿莫西林和克拉霉素治疗1周。然后A组服用兰索拉唑联合替普瑞酮5周，B组服用兰索拉唑，C组服用替普瑞酮5周。在用药前及用药6周后进行内镜检查和EUS检查。
各组至S期的累积愈合率无显著差异（89%、82%对83%，P>0.05）。A组白色瘢痕形成率显著高于B组和C组（67%、36%、50%，P<0.05）。A组溃疡 crater宽度、固有肌层中断长度和低回声区的平均收缩率高于B组和C组（0.792±0.090、0.660±0.105对0.668±0.143，P<0.05）。A组4例、B组1例、C组2例低回声区消失。A组低回声区消失百分比高于其他两组（44%、9%对17%，P<0.05）。A组胃溃疡愈合较好。
质子泵抑制剂与黏膜保护剂联合应用可改善胃溃疡愈合。
