通过内镜超声检查评估胃溃疡愈合质量。
Quality of gastric ulcer healing evaluated by endoscopic ultrasonography.
作者信息
Si Jian-Min, Cao Qian, Wu Jia-Guo
机构信息
Gastroenterology Laboratory, Institute of Clinical Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China.
出版信息
World J Gastroenterol. 2005 Jun 14;11(22):3461-4. doi: 10.3748/wjg.v11.i22.3461.
AIM
To evaluate the quality of gastric ulcer healing after different antiulcer treatment by endoscopic ultrasonography (EUS).
METHODS
The patients were divided into three groups, and received lansoprazole, amoxicillin and clarithromycin for 1 wk. Then group A took lansoprazole combined with tepreton for 5 wk, group B took lansoprazole and group C took tepreton for 5 wk. Endoscopy and EUS were performed before and 6 wk after medication.
RESULTS
There was no significant difference in cumulative healing rate to S stage between the groups (89%, 82% vs 83%, P>0.05). The rate of white scar formation was significantly higher in group A than in groups B and C (67%, 36%, 50%, P<0.05). The average contraction rates of the width of ulcer crater, length of disrupted muscularis propria layer and hypoechoic area were higher in group A than in groups B and C (0.792+/-0.090, 0.660+/-0.105 vs 0.668+/-0.143, P<0.05). The hypoechoic area disappeared in four cases of group A, one of group B and two of group C. The percentage of hypoechoic area disappearance was higher in group A than in the other two groups (44%, 9% vs 17%, P<0.05). Gastric ulcer healing was better in group A.
CONCLUSION
The combined administration of proton-pump inhibitors and mucosal protective agent can improve gastric ulcer healing.
目的
通过内镜超声检查（EUS）评估不同抗溃疡治疗后胃溃疡愈合的质量。
方法
将患者分为三组，接受兰索拉唑、阿莫西林和克拉霉素治疗1周。然后A组服用兰索拉唑联合替普瑞酮5周，B组服用兰索拉唑，C组服用替普瑞酮5周。在用药前及用药6周后进行内镜检查和EUS检查。
结果
各组至S期的累积愈合率无显著差异（89%、82%对83%，P>0.05）。A组白色瘢痕形成率显著高于B组和C组（67%、36%、50%，P<0.05）。A组溃疡 crater宽度、固有肌层中断长度和低回声区的平均收缩率高于B组和C组（0.792±0.090、0.660±0.105对0.668±0.143，P<0.05）。A组4例、B组1例、C组2例低回声区消失。A组低回声区消失百分比高于其他两组（44%、9%对17%，P<0.05）。A组胃溃疡愈合较好。
结论
质子泵抑制剂与黏膜保护剂联合应用可改善胃溃疡愈合。
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