Inoue Ryusuke, Ohkubo Takayoshi, Kikuya Masahiro, Imai Yutaka
The Tohoku University 21st Century COE Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation.
Nihon Rinsho. 2005 Jun;63(6):1005-9.
Systolic blood pressure elevates with increase in age. The frequency of white-coat hypertension and masked hypertension also increase with increase in age. Elderly persons tend to have abnormal circadian rhythm of blood pressure. Home blood pressure measurements are very useful to determine such pathophysiological conditions. Home blood pressure is useful not only for diagnosis of hypertension but also for treatment and management of hypertension; i.e. choice and titration of antihypertensive drugs. A minimal antihypertensive effect and duration of action of antihypertensive drugs are determined by home blood pressure measurements: the latter is established by the comparison of the antihypertensive effect of the drug in the morning with that in the evening, i.e. morning-evening ratio (ME ratio).
收缩压随年龄增长而升高。白大衣高血压和隐匿性高血压的发生率也随年龄增长而增加。老年人往往有异常的血压昼夜节律。家庭血压测量对于确定此类病理生理状况非常有用。家庭血压不仅有助于高血压的诊断，还对高血压的治疗和管理有用；即抗高血压药物的选择和滴定。抗高血压药物的最小降压效果和作用持续时间由家庭血压测量确定：后者通过比较药物在早晨和晚上的降压效果来确定，即早晚比值（ME比值）。
