Capello William N, Dantonio James A, Feinberg Judy R, Manley Michael T
Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, USA.
Instr Course Lect. 2005;54:171-6.
Osteolysis resulting from polyethylene wear debris is one of the most common causes of implant failure in young, active individuals who undergo total hip arthroplasty. Reducing wear may help extend the life of the implant in these patients. Contemporary alumina ceramic/alumina ceramic bearing articulations are harder, scratch resistant, and more hydrophilic than other bearing couples, resulting in reduced wear and reduction of particle load to the surrounding tissue. Therefore, bearings made of alumina ceramic may be a preferable bearing choice for younger, more active patients. To investigate this hypothesis, 495 patients (514 hips), average age 53 years, were enrolled in a prospective, randomized, multicenter study comparing an alumina-on-alumina ceramic bearing to a cobalt-chromium-on-polyethylene bearing control. At an average of 4 years after implantation, no difference in clinical outcome was observed between groups. There were no fractures of the ceramic head or liner, nor were there any revisions caused by the ceramic liner. Another investigational group was added to the study 1 year after enrollment in the original study was closed. The same inclusion/exclusion criteria were used. A total of 194 consecutive patients (209 hips) received an alumina liner that included a thin metal backing designed to allow bearing replacement and ease surgical assembly. At an averagefollow-up of 30 months, no liner or head chips or fractures were observed in this group.
聚乙烯磨损碎屑导致的骨溶解是接受全髋关节置换术的年轻活跃个体植入失败的最常见原因之一。减少磨损可能有助于延长这些患者植入物的使用寿命。当代氧化铝陶瓷/氧化铝陶瓷轴承关节比其他轴承对更硬、更耐刮且更具亲水性,从而减少磨损并降低周围组织的颗粒负荷。因此,氧化铝陶瓷制成的轴承可能是更年轻、更活跃患者的首选轴承。为了研究这一假设,495名患者(514髋),平均年龄53岁,被纳入一项前瞻性、随机、多中心研究,比较氧化铝对氧化铝陶瓷轴承与钴铬对聚乙烯轴承对照。植入后平均4年,两组之间未观察到临床结果的差异。陶瓷头或衬垫没有骨折,也没有因陶瓷衬垫导致的翻修。在原研究入组结束1年后,又增加了一个研究组。使用相同的纳入/排除标准。共有194名连续患者(209髋)接受了氧化铝衬垫,该衬垫包括一个薄金属背衬,旨在便于进行轴承置换和简化手术组装。平均随访30个月,该组未观察到衬垫或头部碎片或骨折。