Pavarana Michele, Nortilli Rolando, Valcamonico Francesca, Romito Silvia, Zanoni Tiziano, Cetto Gianluigi
Department of Clinical and Experimental Medicine, Section of Medical Oncology, University of Verona, Italy.
Tumori. 2005 Mar-Apr;91(2):197-200. doi: 10.1177/030089160509100218.
The aim of this short communication is to discuss the mechanism, modality and treatment of ifosfamide encephalopathy. We present the case of a 52-year-old woman treated with this alkylating agent who developed severe neurotoxicity. It was resolved with administration of Methylene blue, abundant intravenous hydration and interruption of ifosfamide.
本简短通讯的目的是讨论异环磷酰胺脑病的机制、形式及治疗。我们报告一例52岁女性患者，其在接受这种烷化剂治疗后出现严重神经毒性。通过给予亚甲蓝、大量静脉补液及停用异环磷酰胺，病情得以缓解。
