Blumstein Howard, Gorevic Peter D
Mount Sinai Medical Center, New York, NY, USA.
Geriatrics. 2005 Jun;60(6):28-35.
Basic objectives of arthritis therapy are to reduce musculoskeletal pain, slow progression of disease, maintain and improve function and quality of life, and avoid adverse drug reactions. Both nonpharmacologic and pharmacologic approaches may be taken. The former include patient education, cognitive therapy, high-intensity progressive-resistance or strength training, weight control, cold therapy, heat, massage, relaxation and distraction techniques. Guiding principles for the pharmacologic management of musculoskeletal disease in geriatric patients are to 'start low and go slow,' and to provide adequate pain relief. The latter may include the use of topicals, such as 5% lidocaine patches or capsaicin, or orally administered analgesics, such as acetaminophen, tramadol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opiates. Although attractive because of the reduced incidence of serious gastrointestinal adverse reactions, selective COX-2 inhibitors may have significant renal and cardiovascular toxicities, and thus should be used with caution in the older patient with co-morbid diseases affecting these organs. Intraarticular therapies with corticosteroids, or as viscosupplementation, may have a role in the management of osteoarthritis. For patients with inflammatory arthropathies, low-dose systemic steroids or disease-modifying agents are therapeutic. When therapy fails and pain remains intolerable or disabling, surgical options may be considered.
关节炎治疗的基本目标是减轻肌肉骨骼疼痛、减缓疾病进展、维持并改善功能及生活质量,以及避免药物不良反应。可采用非药物和药物治疗方法。前者包括患者教育、认知疗法、高强度渐进性抗阻或力量训练、体重控制、冷疗、热疗、按摩、放松及分散注意力技巧。老年患者肌肉骨骼疾病药物治疗的指导原则是“起始剂量要低,增量要慢”,并提供充分的疼痛缓解。后者可能包括使用外用药物,如5%利多卡因贴剂或辣椒素,或口服镇痛药,如对乙酰氨基酚、曲马多、非甾体抗炎药(NSAIDs)和阿片类药物。选择性COX-2抑制剂虽然因严重胃肠道不良反应发生率较低而具有吸引力,但可能有显著的肾脏和心血管毒性,因此在患有影响这些器官的合并疾病的老年患者中应谨慎使用。关节内注射皮质类固醇或进行粘弹性补充疗法可能在骨关节炎的治疗中发挥作用。对于炎性关节病患者,低剂量全身用类固醇或改善病情的药物具有治疗作用。当治疗失败且疼痛仍然无法忍受或导致残疾时,可考虑手术治疗。